實驗室負責人陳曉穎博士通過系統(tǒng)分析Aβ和Tau兩種AD模型，結(jié)合病人腦組織樣本，首次發(fā)現(xiàn)在AD的發(fā)生發(fā)展中，大腦存在固有免疫和獲得性免疫相互促進的異常免疫應答，打破這一異常免疫應答中的任何一個環(huán)節(jié)將有望能延緩或逆轉(zhuǎn)AD晚期病理改變。相關(guān)工作以長文形式發(fā)表于Nature，并同期被Nature和Natureaging高亮點評。這一研究揭示了神經(jīng)免疫微環(huán)境的組成特點及其在疾病中的動態(tài)演變，為理解神經(jīng)退行性疾病的發(fā)病機制提供了新的理論基礎，對神經(jīng)退行性病變的干預提供了全新的視角和手段。

 

作為清華大學免疫中心/麥戈文/清北生命聯(lián)合中心獨立PI，陳曉穎博士實驗室建設有完善的動物模型平臺、單分子平臺和成像空間，將聚焦于神經(jīng)免疫和代謝在學習記憶與神經(jīng)退行疾病中的作用機制，并探索神經(jīng)退行疾病的干預策略。

 

Dr. Chen is a Principal Investigator and an associate professor of Institute for Immunology at Tsinghua University School of Medicine, Mc Govern Institute as well as Tsinghua-Peking Center for Life Science. Chen lab focuses on understanding the brain-immune interactions in health and disease. The major research directions in her lab are 1) decoding the immune responses in Alzheimer’s disease and therapeutics development, 2) deciphering brain-immune interface and brain-body interaction, and 3) understanding neuronal plasticity throughout AD progression.

 

神經(jīng)免疫課題組負責人介紹

 

陳曉穎博士先后在加州大學洛杉磯分校和華盛頓大學醫(yī)學院從事科學研究工作，師從華盛頓大學醫(yī)學院前神經(jīng)科學系主任Azad Bonni教授（美國醫(yī)學院士， 現(xiàn)任瑞典羅氏總部副總裁）和神經(jīng)病學系主任David Holtzman 教授（美國醫(yī)學院士，前美國神經(jīng)協(xié)會主席），并和免疫系Marco Colonna 教授（美國科學院院士），Ken Murphy教授（免疫學教科書作者），Jonny Kipnis教授（腦膜免疫的開創(chuàng)者）和哈佛醫(yī)學院再生醫(yī)學系Rudy Tanzi教授（衰老中心主任）, Jorfi, Mehdi教授等有深入的國際合作。

 

陳曉穎博士是阿爾茲海默病（AD）研究領(lǐng)域的杰出青年科學家之一，其研究成果促使領(lǐng)域內(nèi)重新認識了外周適應性免疫在重構(gòu)疾病相關(guān)中樞炎癥以及疾病發(fā)生發(fā)展中的核心作用，并據(jù)此提出干預AD新的治療方向。陳曉穎博士創(chuàng)新性科研成果發(fā)表于Nature （2022年，2023年）等頂級期刊，受到廣泛關(guān)注。鑒于其學術(shù)貢獻，陳曉穎博士近幾年來被授予了AD研究的諸多國際大獎, 獲Cure Alz foundation 的Jeffrey L. Morby 獎（年度最影響力研究）, 獲國際阿爾茲海默病協(xié)會（Alzheimer Association）早期職業(yè)成就獎(封面), 受邀在阿爾茲海默病大會做報告，代表女性科學家發(fā)言; 獲華盛頓大學年度神經(jīng)科學最佳研究獎；神經(jīng)科學年會（Sfn）職業(yè)發(fā)展獎；受Immunity 邀請針對神經(jīng)免疫領(lǐng)域進行綜述和展望。因后續(xù)影響力，相關(guān)研究還被邀請在Keystone, AAI, Cell, NIH 50-year Grant Proposal Meeting, Cold Spring Harbor Meeting 等國際大會, 在UCSF, Cornell, WashU, NIH等大學和研究機構(gòu)，在JBP Foundation, Alzheimer's Association Foundation, Alzheimer’s Research Trust Foundation等基金會作口頭報告。Dr. Chen was a faculty member in the Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center at Washington University School of Medicine. She has contributed significant insights into understanding neuronal plasticity during development (Chen., et al., 2017, Journal of Neuroscience; Chen., et al., 2016, 2020, Protein & Cell), learning activities (Chen., et al., 2022, Nature), and neuron-immune interactions in neurodegenerative disease (Chen., et al., 2022, Immunity; Chen., et al., 2023, Nature). She has received a number of honors and awards, including the O’Leary Prize for Best Neuroscience Research at Washington University, the Poletsky Award for Alzheimer’s Disease Research from Washington University, the Tau Consortium Fellowship from Rainwater Charitable Foundation, the Coins for Alzheimer’s Research Trust from Rotary Foundation, the Career Development Award from the Society for Neuroscience, the Early Career Achievement Award from Alzheimer’s Association, and the Jeffrey L. Morby Prize for Best Research in Alzheimer’s Disease from Cure Alzheimer’s Fund. She is a member of Society for Neuroscience, Alzheimer’s Association, American Society for Neurochemistry, American Neurological Association and International Society for Molecular Neurodegeneration. Dr. Chen has reviewed papers for journals, including Immunity, Nature Neuroscience, Alzheimer's & Dementia, Science Advances, Cell Reports, Molecular Neurodegeneration, Journal of Clinical Investigation, Journal of Neuroimmunology (Editorial board member), and Translational Neurodegeneration.

 

實驗室招聘博士后

 

崗位要求與福利待遇：

 

實驗室基本要求：團結(jié)互助，責任心強，視野開闊，有批判精神，學術(shù)誠信。

 

博士后要求：招聘免疫學、神經(jīng)生物學或生物信息學背景博士后，能在導師指導下獨立從事神經(jīng)免疫課題研究。具有免疫學、系統(tǒng)神經(jīng)生物學、分子生物學、單細胞組學、成像、基因編輯、生物信息學經(jīng)驗者優(yōu)先。已獲或者即將獲博士學位。

 

博士后待遇：在國家和清華大學規(guī)定的工作和生活待遇外，根據(jù)個人能力和工作經(jīng)驗給予具有競爭力的津貼，并支持申請國家“博新計劃”、清華“水木學者”、以及生命科學聯(lián)合中心博士后支持計劃和各類基金。

 

請發(fā)送郵件至： xiaoyingchen36@gmail.com。博后申請人除發(fā)送個人簡歷外，附加學術(shù)成果介紹，課題計劃和三名推薦人聯(lián)系方式。

 

Lab members.

 

Highly motivated Postdoctoral Fellows in the field of Immunology, Neuroscience and Bioinformatics.

 

-Ph.D or M.D who have proven record of high-quality publications, experiences with immunology, system neuroscience, molecular biology, single-cell, in vivo calcium imaging, optogenetics, CRISPR or bioinformatics are preferred. 

 

-Strong interests in working with multidisciplinary teams.

 

To apply,

 

Please send your CV, cover letter, research accomplishments, future research interests/plans, and 3 references, including their names, emails, and phone numbers to xiaoyingchen36@gmail.com. Please avoid sending compressed Zip files.

 

Nature|陳曉穎等揭示固有免疫和獲得性免疫在阿爾茲海默病中的關(guān)鍵致病機理

 

Nature|建立神經(jīng)元功能多樣性解析方法并揭示可塑性浦肯野神經(jīng)元及其學習記憶機理

 

信息來源于網(wǎng)絡，如有變更請以原發(fā)布者為準。

 

來源鏈接：

 

http://www.cls.edu.cn/info/1278/5037.htm