一、課題組簡介

張一小，現任中科院生物與化學交叉中心研究員，博士生導師。2015年博士畢業于清華大學生命科學學院。2016至2020年，在美國洛克菲勒大學進行博士后研究并擔任助理研究員。入選國家海外優青項目、上海市海外高層次人才引進計劃，上海科技青年35人引領計劃、上海腦科學與類腦研究中心“求索杰出青年”課題組長，中科院上海分院青年英才培育計劃等。在利用冷凍電鏡研究生物大分子的三維結構方面有超過十年的研究經驗，致力于用冷凍電鏡技術研究富有挑戰性的生物學機制問題。在Nature,Science,MolecularCell,NatureStructural&MolecularBiology,NatureCommunication,PNAS因工作需要，博士后及科研助理。

崗位1：博士后及科研助理

崗位職責（滿足以下1-2項即可）：

1.獨立開展相關課題研究。

2.開展離子通道電生理實驗。

3.開展藥物篩選相關實驗

4.開展細胞生物學實驗。

5.開展冷凍電鏡相關實驗。

6.開展抗體篩選制備相關實驗。

7.完成課題組長交代的其他任務。

崗位要求：

1.具有本科以上的細胞生物學、神經生物學、結構生物學、生物化學等相關專業學歷。

2.工作認真細致，有良好的實驗記錄習慣。

3.具有良好的英文文獻查找及閱讀能力。

4.能長期穩定工作者優先。

三．待遇及福利：

工資和福利按照本人能力、工作業績、中科院生物與化學交叉研究中心和國家有關規定從優，具體待遇面議。郵件標題請注明“應聘職位+姓名“。

五．工作地點：

上海市浦東新區海科路100號13號樓

六．代表性研究論文：

1.Han, Y., Zhou, Z., Jin, R., Dai, F., Ge, Y., Ju, X., Ma, X., He, S., Yuan, L., Wang, Y., Yang, W., Yue, X., Chen, Z., Sun, Y., Corry, B.# , Cox, C. D.#, and Zhang, Y.# (2024). Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 1-9.

2.Zhou, Z., Ma, X., Lin, Y., Cheng, D., Bavi, N., Secker, G.A., Li, J.V., Janbandhu, V., Sutton, D.L., Scott, H.S., Zhang, Y. #, Cox, C.D.# (2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381, 799-804.

3.Yuan, L., Han, Y., Zhao, J., Zhang, Y.#, and Sun, Y#. (2023). Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex. Nature Communications, 14, 6071.

4.Xia, A., Wang, X., He, J., Wu, W., Jiang, W., Xue, S., Zhang, Q., Gao, Y., Han, Y., and Li, Y., Peng, X., Xie, M., Mayer, C. T., Liu, J., Hua, C., Sha, Y., Xu, W., Huang, J., Ying, T., Jiang, S., Xie, Y., Cai, Q., Lu, L. #, Silva, I. T. #, Yuan, Z. #, Zhang, Y. #, and Wang, Q#. (2023). Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history. BMC biology, 21, 205.

5.Zhang, Y., Daday, C., Gu, R., Cox, C.D., Martinac, B., Groot, B., Walz, T. (2021). Visualizing the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 509-514.

6.Dan, J.*, Zhang, Y.*, Lee, C.H., Valencia-Sanchez, M., Zhang, J., Wang, M., Holder, M., Svetlov, V., Tan, D., Nudler, E., Reinberg, D., Walz, T., Armache, K. (2021). Structures of monomeric and dimeric PRC:EZH1 reveal flexible modules involved in chromatin compaction. Nature Communications, 12(1): 714.

7.Sun, Y.*, Zhang, Y.*, Aik, W.S., Yang, X.-C., Marzluff, W.F., Walz, T., Dominski, Z., and Tong, L. (2020). Structure of an active human histone pre-mRNA 3’-end processing machinery. Science 367, 700-703.

8.Zhang, Y.*, Sun, Y.*, Shi, Y., Walz, T., and Tong, L. (2020). Structural Insights into the Human Pre-mRNA 3’-End Processing Machinery. Molecular Cell 77: 800-809.

9.Su, M.*, Zhu, L.*, Zhang, Y.*, Paknejad, N.*, Dey, R., Huang, J., Lee, M.Y., Williams, D., Jordan, K.D., Eng, E.T., Ernst, O.P., Meyerson, J., Hite, R., Walz, T., Liu, W., Huang, X. (2020). Structural basis of the activation of heterotrimeric Gs-protein by isoproterenol-bound b1-adrenergic receptor. Molecular Cell 80:59-71.

10.Nešić, D.*, Zhang, Y.*, Spasic, A.*, Li, J.*, Provasi, D., Filizola, M., Walz, T., and Coller, B.S. (2020). Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex. Arteriosclerosis, Thrombosis, and Vascular Biology. 119.313671.

11.Yu, J.*, Zhang, B.*, Zhang, Y.*, Xu, C.Q., Zhuo, W., Ge, J., Li, J., Gao, N., Li, Y., and Yang, M. (2018). A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein & Cell 9, 629-639.

12.Lees, J.A.*, Zhang, Y.*, Oh, M.S., Schauder, C.M., Yu, X., Baskin, J.M., Dobbs, K., Notarangelo, L.D., De Camilli, P., Walz, T., Renisch, K. (2017). Architecture of the human PI4KIIIalpha lipid kinase complex. Proc Natl Acad Sci. U.S.A 114, 13720-13725.

13.Sun, Y.*, Zhang, Y.*, Hamilton, K., Manley, J.L., Shi, Y., Walz, T., and Tong, L. (2017). Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc Natl Acad Sci. U.S.A 115, E1419-E1428.

14.Zhang, Y., Ma, C., Yuan, Y., Zhu, J., Li, N., Chen, C., Wu, S., Yu, L., Lei, J., and Gao, N. (2014). Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome. Nature Structural & Molecular Biology 21, 1042-1046.

15.Wu, S., Tutuncuoglu, B., Yan, K., Brown, H., Zhang, Y., Tan, D., Gamalinda, M., Yuan, Y., Li, Z., Jakovljevic, J., et al. (2016). Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature 534, 133-137.

16.Li, N., Zhai, Y., Zhang, Y., Li, W., Yang, M., Lei, J., Tye, B.K., and Gao, N. (2015). Structure of the eukaryotic MCM complex at 3.8 A. Nature 524, 186-191.

* indicates co-first authors, # indicates co-corresponding authors

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來源鏈接：

https://www.ircbc.cn/view.do?id=3278

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