Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Translational Development at Celgene

Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases. At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Investigational compounds are being studied for patients with hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), pancreatic cancer and lung cancer.

Translational Development is a department within the Research and Development organization that facilitates the transition of drug candidates from drug discovery through clinical development by enabling rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action. The function additionally explores mechanisms of resistance, rational drug combinations and product differentiation. The San Francisco-based late stage myeloid translational group supports multiple disease areas, including MDS, AML and beta thalassemia. This group leads the development of translational strategies to support the development, and maximize the potential, of Celgene therapies and conduct post-clinical proof-of-concept studies, including registrations and life-cycle management.

Summary/Scope

We are seeking a talented postdoctoral fellow in the Translational Development and Diagnostics group based in San Francisco, CA to explore the role of iron homeostasis in myeloid disorders. The candidate will use a variety of tools, ranging from in vivo models of disease, primary cell culture and in vitro systems to understand the effect of various therapeutics on iron regulation in congenital anemias, myeloid neoplasms and/or myeloproliferative disorders.

Responsibilities will include, but are not limited to, the following:

Plan and conduct experiments to characterize iron metabolism in a variety of biological systems, including 2D and 3D immortalized and primary cell cultures. Characterize iron homeostasis in physiologically relevant in vivo disease models of anemia and cancer. Establish ex vivo cell culture and other systems to test hypotheses related to iron regulation. Prepare and deliver presentations within the department and externally. Author study reports and peer-reviewed publications

Skills/Knowledge Required:

Ph.D. degree in molecular and cellular biology, genetics, physiology, or a related discipline and at least 1 year of laboratory experience. iron metabolism, red blood cell biology, and/or the pathophysiology of anemia and myeloproliferative disorders. A track record of rigorous bench research and independent thinking, with at least one first-author publication. Highly motivated to contribute to the development of therapeutics for unmet medical needs. Experience with small animal work. Multiparameter flow cytometry. Bone marrow, liver and other primary cell culture systems. Knowledge of transcriptional profiling, proteomics, or metabolomics would be a plus. Enthusiasm to work in a team-based, collaborative environment. Strong verbal and written communication and organization skills. Ability to prioritize and manage time efficiently.

Prerequisites: Ph.D. in a scientific discipline with at least 1 year of laboratory experience, preferred.

Note: Postdocs will be eligible for Celgene benefits but will not be entitled to receive Celgene equity, bonuses or annual merit increases. Minimum relocation assistance will be offered on a case by case basis only.

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Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

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