招聘簡介：

　　職稱：博士后培訓研究員 - 莫洛德索夫實驗室

　　地點：倫敦米德蘭路弗朗西斯克里克研究所

　　合同：定期（4年），全職

　　薪酬：具有競爭優勢，受技能和經驗的影響

　　空缺ID：10846

　　簡短的摘要

　　弗朗西斯克里克研究所的機械生物學和生物物理學小組正在尋找一位高素質的生物化學家加入我們的跨學科團隊。 Maxim Molodtsov領導，我們研究分子原理和力量，導致精確和大規模的DNA重排和準確的DNA分離，我們使用廣泛的單分子技術，包括力譜，單分子成像和單分子FRET。我們還繼續開發新工具，以了解移動和重組DNA的機器的機制。在過去，我們對驅動DNA組織和細胞骨架重排的機制進行了重要發現，并開發了新的成像物理工具。

　　候選人應具有蛋白質生物化學和分子生物學的扎實背景。預計它們具有強大的出版記錄和對定量生物物理方法和/或單分子方法的濃厚興趣。不需要顯微鏡，生物物理和/或力譜的經驗，但歡迎。

　　英文原文：

　　Job title: Postdoctoral Training Fellow – Molodtsov Laboratory

　　Location: The Francis Crick Institute, Midland Road, London

　　Contract:Fixed-term (4 years), full time

　　Salary:Competitive with benefits, subject to skills and experience

　　Vacancy ID: 10846

　　Short summary

　　The mechanobiology and biophysics group at the Francis Crick Institute is looking for a highly qualified biochemist to join our interdisciplinary team. Lead by Maxim Molodtsov, we investigate molecular principles and forces that lead to precise and large-scale DNA rearrangements and accurate DNA segregation and we use broad range of single-molecule techniques including force spectroscopy, single-molecule imaging and single-molecule FRET. We also continue developing new tools to understand mechanistics of the machinery that moves and reorganizes DNA. In the past we made important discoveries of mechanisms that drive DNA organization and cytoskeleton rearrangements as well as developed new physical tools for imaging.

　　Candidates should have a solid background in protein biochemistry and molecular biology. They are expected to have a strong publication record and strong interest in quantitative biophysical methods and/or single-molecule methods. Experience with microscopy, biophysics and/or force spectroscopy is not required but welcome.

　　Project scope

　　Positions are available in two areas: (1) Microtubule-based cytoskeleton rearrangements and chromosome movements; (2) DNA organization and segregation during cell division.

　　The successful candidate will use in vitro assays to reconstitute biochemically multicomponent systems that drive these processes. To investigate the underlying mechanisms, they will use multi-wavelength TIRF microscopy and/or single-molecule imaging including single-molecule FRET and/or optical trapping as well as advanced data processing.

　　The project will benefit from close collaborations with leading experts in single-molecule imaging and force-spectroscopy both within the group and externally at the Crick and Physics Department of the University College London with which we are affiliated. The candidate is expected to drive their own project and participate and contribute to interdisciplinary team that works on developing new tools for investigating reorganization of cytoskeleton and DNA by motor and non-motor complexes that generate and respond to mechanical forces.

　　About us

　　The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

　　An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

　　The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

　　The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

　　o    If you are interested in applying for this role, please apply via our website.

　　o    The closing date for applications is 20 June 2019 at 23:30.

　　All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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