Postdoctoral Researcher

Deutsches Krebsforschungszentrum

Description

Position: Postdoctoral Researcher

Department: Systems Biology of Signal Transduction

Code number: 2020-0341

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Job description:

To unraveling mechanisms regulating the dynamics of BMP signal transduction and its impact on hepcidin expression with a systems biology approach, we are looking for a highly motivated postdoc. The candidate will develop a mass spectrometry-based pipeline for the quantitative analysis of plasma proteins to identify plasma factors and correlate these factors with the iron status. In collaboration with internal and external partners, he/she will develop a dynamic pathway model of BMP signal transduction in hepatocytes. To obtain absolute quantitative data for the calibration of the parameters of the mathematical model, the mass spectrometry approach will be extended to simultaneously target several cell surface receptors and cellular proteins. He/she will utilize the developed integrative model to uncover iron regulatory mechanisms that are altered in chronic liver disease.

Requirements:

The successful performance of this project requires a highly qualified and motivated researcher with a sound knowledge of biochemical techniques and mass spectrometry as well as an understanding of mathematical modeling and systems biology approaches. Given the collaborative and interdisciplinary aspects of this project, communication skills are key.

We offer:

  Interesting, versatile workplace

  International, attractive working environment

  Campus with modern state-of-the-art infrastructure

  Salary according to TV-L including social benefits

  Possibility to work part-time

  Flexible working hours

  Comprehensive further training program

  Access to the DKFZ International Postdoc Program

Earliest possible start date: as soon as possible

Duration: The position is initially limited to 2 years with the possibility of prolongation.

The position can in principle be part-time.

Application deadline: 21.01.2021

Contact:

Prof. Dr. Ursula Klingmüller Phone +49 (0)6221/42-4481

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https: // www. dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

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