一、中心簡介

首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家及其科研團隊，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。

二、實驗室介紹

閆致強，2004年獲復旦大學學士學位。2004-2009年分別于中國科學院神經科學研究所、北京生命科學研究所以及中科院生物物理研究所進行博士研究并獲得博士學位。2009-2013加州大學舊金山分校及霍華德·休斯醫學研究所師從美國科學院院士詹裕農、葉公杼(Yuh-Nung Jan,Lily Jan)進行博士后研究。2013年任復旦大學生命科學學院教授、博士生導師，獲得上海高校特聘教授（東方學者，2014）、上海市青年科技啟明星（2014），2020年加入深圳灣實驗室分子生理所任資深研究員、副所長。2024年加入首都醫科大學任基礎醫學院院長、博士生導師，首都醫學科學創新中心任資深研究員、醫學生理研究所所長。以通訊作者在Neuron、Nature Structural & Molecular Biology、PNAS、Nature Communications、eLife、Cell Reports、Genome Research等國際高水平雜志發表多篇論文。獲4項國家科技部重大研究計劃、2項國家自然科學基金委面上項目支持。

三、實驗室研究方向

閆致強實驗室長期從事感覺神經生物學的研究，綜合運用分子生物學、蛋白相互作用和結構分析、電生理記錄、神經回路的光遺傳、化學遺傳和成像等技術手段，結合藥物篩選和基因編輯小鼠模型，進行聽覺、觸覺、渴覺等感覺受體的鑒定和工作機制研究，感覺系統神經回路，以及感覺系統疾病的機理和治療，并探索這些感覺受體在其他重要生理功能中的作用。

1.聽覺、觸覺、痛覺、濕度感覺、渴覺等感覺受體的鑒定，其裝配和工作機制研究，以及這些受體在其他重要生理過程中的作用，例如消化和免疫反應。

2.解析感覺受體離子通道及其復合物的蛋白結構、分析離子通透性和門控機制等。

3.鑒定在觸覺、痛覺、平衡覺、聽覺、渴覺、內臟感覺等的關鍵神經細胞群和神經回路。

4.研究遺傳性耳聾的致病機理、診斷以及基因治療。

代表性文章

Genome Research, 2022, 32: 1573-1584. PMID: 35760561

Nature Communications, 2022, 13: 3814. PMID:  35780140

PNAS, 2021, 118: e2106459118. PMID: 34848538

eLife, 2021, 10: e58388. PMID: 34101577

Neuron, 2020, 105: 310–321. PMID: 31761710

四、崗位信息

01博士后

1）主要職責

1.在課題組組長指導下開展科研工作；

2.協助指導研究生工作以及撰寫論文或基金申請。

2）任職要求

1.具有神經生物學、分子生物學與生物化學、生理學、細胞生物學、結構生物學、藥物化學等生物醫學研究相關專業背景的人員，即將獲得博士學位或已獲得博士學位；

2.以第一作者身份在領域內主流期刊上發表過或即將發表研究論文，能夠獨立開展研究工作；

3.具備獨立開展科研工作和指導研究生能力，具有科研熱情和嚴謹的科研態度；

4.具備良好的英語讀寫和日常交流能力，能夠使用英文撰寫論文。

02副研究員/助理研究員

1）主要職責

1.在課題組組長指導下開展科研工作；

2.協助指導研究生工作以及撰寫論文或基金申請。

2）任職要求

1.具有神經生物學、分子生物學與生物化學、生理學、細胞生物學、結構生物學、藥物化學等生物醫學研究相關專業背景的人員；

2.獲得國內外一流研究機構博士學位或博士后研究經歷；

3.在領域內主流期刊上發表過研究論文；

4.具備獨立開展科研工作和指導研究生能力，具有科研熱情和嚴謹的科研態度；

5.具備良好的英語讀寫和日常交流能力，能夠使用英文撰寫論文。

03科研助理

1）主要職責

1.完成課題組組長安排的實驗任務；

2.協助處理實驗室行政事務。

2）任職要求

1.大學本科學歷及以上，生物學、基礎醫學、微生物學等相關專業；

2.掌握常規分子克隆、細胞培養、動物實驗和/或膜片鉗記錄等操作及原理，有實驗室研究工作經歷或病毒載體包裝經驗者優先；

3.具備良好的溝通能力和團隊協作能力；

4.具備良好的英語讀寫和日常交流能力。

04技術員

1）主要職責

1.完成實驗室安排的日常實驗；

2.負責維護實驗室日常工作和行政事務。

2）任職要求

1.大學本科學歷，生物學、基礎醫學、微生物學等相關專業；

2.掌握常規分子克隆、細胞培養、動物實驗等操作及原理；

3.具備良好的溝通能力和團隊協作能力。

05實驗室管理員

1）主要職責

1.協助實驗室日常管理和維護工作，包括實驗試劑及耗材管理、實驗儀器設備維護、實驗室衛生管理等；

2.協助項目經費管理和費用報銷工作；

3.協助實驗室安全管理工作，危化品管理以及特種設備的使用和實驗材料滅菌等；

4.負責和監控實驗動物的飼養管理工作。

2）任職要求

1.本科學歷及以上，生命科學、醫學等相關專業；

2.具有良好的溝通能力和團隊協作能力；

3.熟悉各種日常辦公軟件；

4.有實驗室工作經驗或管理經驗者優先考慮。

五、福利待遇

1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；

2.享受五險一金、帶薪年假、體檢和補充醫療保險等；

3.支持個人職業發展，提供必要的工作相關專業培訓。

六、申請方法

應聘者請將個人簡歷、研究興趣或計劃，以及1-2份推薦信，以及其他能證明科研能力的相關電子文件發送到郵箱zqyan@cimrbj.ac.cn ，郵件主題請注明“應聘者名字+具體應聘職位”。

聯系人：閆老師

聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心

本招聘長期有效，至招聘到合適人選為止。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

Dr. Zhiqiang Yan obtained his bachelor's degree from Fudan University in 2004, Then, he pursued his Ph.D. degree in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, National Institute of Biology Sciences, Beijing & Institute of Biophysics, Chinese Academy of Sciences form 2004-2009. He received postdoctoral training in both Lily Jan' group and Yuh Nung Jan' group at Howard Hughes Medical Institute &University of California at San Francisco, San Francisco, USA. In 2013, he was appointed as a professor in Fudan University. Then, he joined Shenzhen Bay Laboratory as a senior principal investigator at 2020 and appointed as deputy director at 2022. Then, he joined Capital Medical University as the Dean and doctoral supervisor of the school of Basic Medical Sciences, and joined the Chinese Institutes for Medical Research (CIMR) in Beijing as a senior principal investigator and director of the Institute for Medical Physiology at 2024. He has won honors such as Human Frontier Science Program (HFSP) Long-term Fellowship (2010), Shanghai Youth Science and Technology Venus (2014), The Shanghai Rising-Star Program (2014), etc. Dr. Yan has published papers as corresponding author (including co-authors) in journals including Neuron, Nature Structural & Molecular Biology, PNAS, Nature Communications, eLife, Cell Reports, etc. He was supported by 4 National Key Research and Development Projects of China and 2 general programs of the National Natural Science Foundation of China.

Research Direction

The Yan laboratory studies sensory neurobiology, focuses on identifying the receptors and neural circuits for sensation and interoception, studies their working mechanism and related the diseases in sensory system.

a. Identify the receptors for hearing, touch, pain, and thirst sensation, study the gating and assembly of the related sensory transduction complex, and explore their functions in various physiological processes, such as digestion and immunity.

b. Analysis of the protein structures of sensory receptor ion channels and their complexes, as well as the examination of ion permeability and gating mechanisms.

c. Map the critical neuronal groups and circuits for sensation and interoception such as touch, pain, vestibular and thirst sensation.

d. Study pathogenic mechanism, diagnosis and treatment of congenital hearing loss.

Representative Publications

Genome Research, 2022, 32: 1573-1584. PMID: 35760561

Nature Communications, 2022, 13: 3814. PMID:  35780140

PNAS, 2021, 118: e2106459118. PMID:  34848538

eLife, 2021, 10: e58388. PMID: 34101577

Neuron, 2020, 105: 310–321. PMID: 31761710

Open Positions：

01、Postdoctoral Researcher

Main Responsibilities

a. Carry out scientific research under the guidance of the leader of the research group.

b. Assist in supervising graduate students, writing papers, and applying for grants.

Qualifications

a. Backgrounds in neurobiology, molecular biology and biochemistry, cell biology, structural biology, pharmaceutical chemistry, etc. Either about to obtain a Ph.D. or recently obtained a Ph.D. degree.

b. Published or about to publish research papers as the first author in reputable journals in the field.

c. Self-motivated and independent researcher capable of independently conducting scientific research and assisting to supervise graduate students.

d. Proficient in English reading, writing, and daily communication. Capable of writing papers in English.

02、Research Associate Investigator

Main Responsibilities

a. Carry out scientific research under the guidance of the leader of the research group.

b. Assist in supervising graduate students, writing papers, and applying for grants.

Qualifications

a. Backgrounds in neurobiology, molecular biology and biochemistry, cell biology, structural biology, pharmaceutical chemistry, etc.

b. Doctoral degree or post-doctoral research experience from first-class research institutions at home and abroad.

c. Published research papers in reputable journals in the field.

d. Self-motivated and independent researcher capable of independently conducting scientific research and assisting to supervise graduate students.

e. Proficient in English reading, writing, and daily communication. Capable of writing papers in English.

03、Research Assistant

Main Responsibilities

a. Aim to complete the experimental tasks assigned by the group leader.

b. Assist in handling laboratory administrative affairs.

Qualifications

a. A B.S or higher degree in biology, basic medical science, microbiology and other relevant majors is required.

b. Research experience in molecular biology, biochemistry, cell biology, mouse studies and/or patch-clamp recording, or viral vector producing is preferred.

c. Self-motivated researcher with good communication skill and teamwork ability.

d. Proficient in English reading, writing, and daily communication.

04、Technician

Main Responsibilities

a. Aim to complete the experimental tasks assigned by the group leader.

b. Responsible for maintaining the daily operations and administrative affairs of the laboratory.

Qualifications

a. A B.S or higher degree in biology, basic medical science, microbiology and other relevant majors is required.

b. Research experience in molecular biology, biochemistry, cell biology, and mouse studies.

c. Self-motivated researcher with good communication skill and teamwork ability.

05、Lab Manager

Main Responsibilities

a. Assist in the daily management and maintenance of the laboratory, including the management of experimental reagents and consumables, the maintenance of experimental equipment, and the management of laboratory hygiene.

b. Assist in the management of project funds and expense reimbursement work.

c. Assist in the safety management of the laboratory, the management of hazardous chemicals, the use of special equipment, and the sterilization of experimental materials.

d. Be responsible for and monitor the breeding and management of laboratory animals.

Qualifications

a. Have a bachelor's degree or above, in life science- or medicine-related majors.

b. Have excellent communication skills and teamwork skills.

c. Familiar with daily office software.

d. Priority will be given to applicants with laboratory management experience.

Welfare Treatment

a.Competitive salary based on the job applicant's work experience and abilities (salary negotiable).

b. Social insurance, paid annual leave, physical examination and supplementary medical insurance, etc.

c.Supporting personal career development and providing necessary job related professional training.

How to apply

To apply, please send personal resume, research interest or plan, 1-2 letters of recommendation, and other materials demonstrating research capabilities to zqyan@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Zhiqiang Yan

Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing

This recruitment is valid for the long term until a suitable candidate is recruited.

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應聘職位名稱+姓名+學歷+專業+中國博士人才網）