西雅圖兒童研究所2020年博士后招聘（結核病藥物研發）

TB remains a serious global health problem and there is an urgent need for new therapeutic agents and an increased understanding of antibiotic resistance. The Parish Lab is looking for a post-doctoral scientist to work on a tuberculosis drug discovery project. The successful candidate will work in a multi-disciplinary research environment interacting with chemists and biologists. The main research project is to determine the mode of action of new compounds classes under development as TB drugs. Work will also involve target identification, confirmation, and validation, as well as determining mechanisms of drug resistance.

Description of Responsibilities:

Conduct a research and development project

Design and implement research plans

Work under Biosafety Level 3 conditions with Mycobacterium tuberculosis

Troubleshoot and solve experimental and technical problems

To prepare and present papers, reports, and presentations of current research work

Write manuscripts and assist with grant preparation

Write standard protocols and validation data packages

Oversee quality control and data integrity

May supervise one or more research assistants

Specific duties include:

Conduct research into mechanism of kill of new inhibitors

Use multiple approaches to identify and validate drug targets

Research into mode of resistance of new inhibitors

Run a wide range of microbiological and cellular assays

Culture and genetic manipulation of mycobacteria

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Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child’s immune system defeat cancer, and made other major contributions to pediatric medicine.

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