首都醫(yī)學(xué)科學(xué)創(chuàng)新中心（簡稱創(chuàng)新中心）是北京市新成立的具有獨立法人資格的新型研發(fā)機(jī)構(gòu)。創(chuàng)新中心以推動醫(yī)學(xué)科學(xué)發(fā)展、改善人類健康為目標(biāo)，開展生物醫(yī)學(xué)研究，致力于提升醫(yī)學(xué)科學(xué)創(chuàng)新與成果轉(zhuǎn)化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學(xué)家，與首都醫(yī)學(xué)教育和科學(xué)研究優(yōu)質(zhì)資源緊密合作，打造多學(xué)科交叉融合的科研平臺，綜合自由探索、醫(yī)學(xué)目標(biāo)導(dǎo)向、有組織科研等途徑，實踐新型科研模式和體制機(jī)制，逐步推進(jìn)醫(yī)教研產(chǎn)的深度融合，培養(yǎng)適應(yīng)醫(yī)學(xué)科學(xué)創(chuàng)新發(fā)展的優(yōu)秀人才。

一、實驗室介紹

張翼研究員在北京大學(xué)獲得學(xué)士和博士學(xué)位，已加入首都醫(yī)學(xué)科學(xué)創(chuàng)新中心（CIMR）創(chuàng)建獨立實驗室。張翼實驗室的主要研究興趣是開發(fā)新型計算和實驗方法，從靜態(tài)、離散的樣本中準(zhǔn)確重建出動態(tài)、連續(xù)的生物學(xué)過程的歷史軌跡，以便更好地理解發(fā)育、衰老、疾病發(fā)生發(fā)展的分子機(jī)制，為重大疾病的診斷和治療提供理論依據(jù)與技術(shù)支撐。

本實驗室的工作特點為干濕結(jié)合、學(xué)科交叉。歡迎不同背景的研究同事加入團(tuán)隊。

二維碼（請點擊鏈接查看詳情）_掃碼了解更多

二、實驗室研究方向

實驗室將綜合利用深度學(xué)習(xí)、生物信息學(xué)、分子生物學(xué)、細(xì)胞生物學(xué)、動物模型、單分子測序、單細(xì)胞測序等技術(shù)和手段，開展（不限）以下課題研究：

1.開發(fā)前沿計算工具，即新型計算生物學(xué)方法，用于解析復(fù)雜數(shù)據(jù)中隱含的動態(tài)特征信息。

2.開發(fā)新型單細(xì)胞、單分子水平的實驗和計算方法，從靜態(tài)樣本中重建生物過程的動態(tài)歷史，鑒定其中關(guān)鍵的分子事件。

3.綜合運用正向遺傳學(xué)篩選、反向遺傳學(xué)操作、單分子測序、單細(xì)胞多組學(xué)分析手段，解析表觀基因組復(fù)制的分子機(jī)制，特別是在衰老、疾病中表觀遺傳信息復(fù)制的分子機(jī)制。

三、主要成果與貢獻(xiàn)

1.開發(fā)從單細(xì)胞ATAC數(shù)據(jù)中計算細(xì)胞分裂年齡的方法 (Nat.Biotech., 2024)

2.發(fā)現(xiàn)DNA二級結(jié)構(gòu)影響表觀基因組復(fù)制 (BioRxiv, 2024)

3.開發(fā)將神經(jīng)活動轉(zhuǎn)化為遺傳可操作對象的方法 (J.Neurogenetics, 2012)

代表性文章

Nature Biotechnology, 2024.PMID: 38724668.

Advanced Science, 2024, 11: e2308438.PMID: 38582099.

Genome Biology, 2024, 25:117.PMID: 38715110.

Neuro-Oncology, 2022, 24: 903-913.PMID: 34918118.

Journal of Neurogenetics, 2012, 26: 89-102.PMID: 22236090.

四、崗位信息

01、科研助理

1）崗位職責(zé)

1.獨立或協(xié)助團(tuán)隊開展課題研究；

2.協(xié)助實驗室運行管理。

2）任職要求

1.大學(xué)本科學(xué)歷及以上，生物學(xué)、生物信息學(xué)、演化生物學(xué)及其它相關(guān)專業(yè)；

2.掌握分子生物學(xué)操作及原理，有二代測序、三代測序、細(xì)胞生物學(xué)、模式動物等研究經(jīng)歷優(yōu)先；

3.具備良好的溝通能力和團(tuán)隊協(xié)作能力；

4.具備良好的英語讀寫和日常交流能力。

02、博士后

1）崗位職責(zé)

1.以科學(xué)研究工作為主，在PI指導(dǎo)下獨立開展研究工作，按計劃完成博士后研究任務(wù)；

2.與合作導(dǎo)師共同承擔(dān)科研課題，發(fā)表高水平研究論文，申請各類科研項目、專利，協(xié)助指導(dǎo)研究生工作。

2）任職要求

1.具有生命科學(xué)、生物信息學(xué)、計算機(jī)科學(xué)、物理學(xué)或其他相關(guān)領(lǐng)域的研究背景，在國內(nèi)外已獲得或即將獲得博士學(xué)位（原則上不超過3年），有物理、數(shù)學(xué)、計算機(jī)、生物信息學(xué)訓(xùn)練背景或三代測序、單細(xì)胞測序、Perturb-seq實驗背景者優(yōu)先考慮；

2.以第一作者身份在領(lǐng)域內(nèi)主流期刊上發(fā)表過或即將發(fā)表研究論文（在BioRxiv上已公開），能夠獨立開展研究工作；

3.具備獨立開展科研工作和指導(dǎo)研究生能力，具有嚴(yán)格的學(xué)術(shù)道德、高漲的科研熱情、嚴(yán)謹(jǐn)?shù)目蒲袘B(tài)度、良好的溝通能力和團(tuán)隊合作精神，具有誠實健康、樂觀堅強、有上進(jìn)心、勤勞刻苦的個人品質(zhì)；

4.具有高效的信息檢索、英語文獻(xiàn)閱讀、論文撰寫能力，具備應(yīng)有的分子生物學(xué)或生物信息學(xué)基本技能，熟知技術(shù)背后原理。

五、福利待遇

1.根據(jù)應(yīng)聘者的工作經(jīng)驗和能力，提供具有市場競爭力的薪酬（詳情面談）；

2.享受五險一金、帶薪年假、體檢和補充醫(yī)療保險等；

3.支持個人職業(yè)發(fā)展，提供必要的工作相關(guān)專業(yè)培訓(xùn)。

六、申請方法

應(yīng)聘者請將個人簡歷、研究興趣或計劃，以及2-3名推薦人（僅限博士后應(yīng)聘）的姓名及聯(lián)系方式，以及其他能證明科研能力的相關(guān)電子文件發(fā)送到郵箱 zhangyi@cimrbj.ac.cn，郵件主題請注明“應(yīng)聘者名字+具體應(yīng)聘職位”。

聯(lián)系人：張老師

聯(lián)系地址：北京市豐臺區(qū)右安門外西頭條10號-首都醫(yī)學(xué)科學(xué)創(chuàng)新中心

本招聘長期有效，至招聘到合適人選為止。

另外本實驗室歡迎有對生物信息學(xué)感興趣的各階段實習(xí)生、聯(lián)培生前來學(xué)習(xí)交流。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Zhang laboratory develop novel computational and experimental methods to track human development, aging, and disease across time domains on single-cell, single-molecule resolution.

The laboratory conducts cross-disciplinary research with a combination of computational and experimental biological methods.We welcome colleagues with background in physics, computer science, biology, bioinformatics, and medicine to join our team.

Lab website:QR code→（請點擊鏈接查看詳情）

Major Research Projects

The laboratory uses a combination of deep learning, bioinformatics, forward and reverse genetics, and sequencing approaches on human samples and animal models, to:

a.Develop methods to extract latent information from biological data.

b.Develop novel methods to resolve dynamic biological process from static samples.

c.Dissect the molecular mechanism of epigenome replication, particularly in aging and disease.

Major Contributions

a.Developed method to decode cell replicational age from single-cell ATAC-seq data (Nat.Biotech., 2024)

b.Provided evidence for how DNA secondary structure affect epigenome replication (BioRxiv, 2024)

c.Developed tools to convert Drosophila neuronal activity into genetic manipulable object (J.Neurogenetics, 2012)

Representative Publications

Nature Biotechnology, 2024.PMID: 38724668.

Advanced Science, 2024, 11: e2308438.PMID: 38582099.

Genome Biology, 2024, 25:117.PMID: 38715110.

Neuro-Oncology, 2022, 24: 903-913.PMID: 34918118.

Journal of Neurogenetics, 2012, 26: 89-102.PMID: 22236090.

Open Positions

Research Assistant

Main Responsibilities

a.Conducting research projects either independently or in a team.

b.Assisting PI in lab routine management.

Qualifications

a.B.S.or higher degree in biology, bioinformatics, evolutionary biology or other relevant majors is required.

b.Research experience in bioinformatics, next-generation sequencing, single-molecule sequencing (Nanopore or PacBio), cell biology and/or model animal works is preferred.

c.Self-motivated researcher with good communication skill and teamwork ability.

d.Proficient in English reading, writing, and daily communication.Passed CET 6.

Postdoctoral Researcher

Main Responsibilities

a.Conducting research projects independently.

b.Assisting PI to mentor graduate students, and write grant proposals and manuscripts.

Qualifications

a.Backgrounds in computer science, physics, bioinformatics, biology or biomedical engineering.Either about obtaining a Ph.D.or recently obtaining a Ph.D.degree (ideally within the last 3 years).

b.Have first author paper(s) published in (or accepted by) reputable journals in the field.

c.Have the ability to independently carry out scientific research and guide graduate students, have scientific research enthusiasm and rigorous scientific research attitude.

d.Learns quickly.

e.Strong research experience in either:

 (i) Perturb-seq, single-cell sequencing, single-molecule sequencing, epigenomics.

 (ii) Bioinformatics, deep learning, algorithm development.

f.Proficient in English reading, writing, and daily communication.

Compensation and Benefits

a.Competitive salary based on the applicant’s work experience and ability (salary negotiable).

b.Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c.Opportunities for career development and available professional guidance.

How to apply

To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zhangyi@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.

Contact person: Yi Zhang

This recruitment is valid for the long term until a suitable candidate is recruited.

Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in cellular immunotherapy to come and exchange ideas.

信息來源于網(wǎng)絡(luò)，如有變更請以原發(fā)布者為準(zhǔn)。

來源鏈接：

https://mp.weixin.qq.com/s/mBLZLfaP2pCEyeM7igwmmA

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）